Key Dates – February 2020

Please contact customerservices lexology. From 1 April , both award limits will be subject to automatic inflation-linked adjustments. The FCA confirmed that, having considered the feedback received in over responses, it would implement its proposals as consulted on. The following key issues emerged:. It is clear from the feedback received by the FCA that there are a number of concerns as to whether the FOS has the necessary resources or expertise to deal effectively with complex and high value complaints. Notwithstanding the areas identified in need of improvement by an independent review in , the FCA has maintained that the FOS will have the capability and capacity to make decisions on this type of complaint. In order to address some of these concerns, the FCA has indicated that the FOS will shortly publish information about additional governance arrangements including senior oversight that will apply to high value complaints, together with examples to help firms understand whether a complaint would be better placed in the courts. A key area of contention revolved around concerns of PII insurers that the prospect of an increased award limit would likely cause the PII market to shrink and likely necessitate significant premium increases. Although accepting these views, the FCA emphasised that it did not think that the worst-case scenarios will materialise. The FCA has however said that, in order to assist PII insurers understand key risks going forward, it will continue to publish relevant information about its view of markets that may have conduct issues and are a concern for PII insurers.

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Sadly, we have had to take the decision not to hold the Festival of Speed and Revival this year. All ticket holders have the option to rollover their tickets or request a refund. As well as the options to rollover tickets to or request a refund, any ticket-holder can also choose to exchange a proportion of their ticket value in return for additional GSA benefits. For those without tickets that would like to join the GSA and show their support, there are a range of GSA levels with various benefits at each level in recognition of your support.

We appreciate this is a difficult time for everyone, and one which is surrounded by uncertainty.

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Initially, opioid signaling had been thought to be mainly inhibitory in nature. However, it has been shown that opioids can activate specific signaling pathways and induce immediate early gene IEG transcription in brain. IEGs can then regulate the transcription of other genes, leading to changes in neuronal function in response to extracellular stimuli.

This study was designed to identify brain regions that demonstrate specific induction of the IEG c-fos, a component of the AP-1 transcription factor, in response to acute morphine, and to contrast this induction with the stressful effects of the injection itself. Animals were then sacrificed 15, 30, or 60 min after injection. Specific induction of c-fos mRNA by morphine was seen in dorsomedial caudate-putamen, paraventricular nucleus of the thalamus, central and intralaminar thalamic nuclei, dorsal central grey, superior colliculus, lateral parabrachial nucleus, inferior olivary complex, and caudal nucleus tractus solitarius.

These findings represent the first complete anatomical mapping of c-fos induction in rat brain, and show that acute morphine administration alters gene expression in several areas related to known functional properties of opioids. However, regions showing c-fos induction are not all classically associated with opioid receptors and opioid-mediated effects. These findings are considered in the context of the effects of opioids on neural circuitry as well as direct, receptor-mediated effects of morphine on neural cells.

Key words : anatomy, immediate early genes, opioids, neural circuitry, nociception, transcriptional regulation.

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More scholars are demanding that journals offer free online access to their contents. One of the most important FOS initiatives to date is the Budapest Open.

This dataset shows quantifications of Fos protein expression in sites distal to CeA after optogenetic stimulation of CeA ChR2 during certain behavioral conditions. Specifically, rats were either earning sucrose or cocaine rewards, or interacting with a shock rod, brains were extracted 90 min later and Fos protein expression was measured in various brain sites see document. Atlas pages with which Fos protein was measured are listed in the first sheet.

Dataset supporting: Warlow, S. The central amygdala recruits mesocorticolimbic circuitry for pursuit of reward or pain. Nat Commun 11 , Here intense maladaptive attractions were created in laboratory rats by pairing optogenetic channelrhodopsin ChR2 stimulation of central nucleus of amygdala CeA in rats with encountering either sucrose, cocaine, or a painful shock-delivering object. Pairings made the respective rats pursue either sucrose exclusively, or cocaine exclusively, or repeatedly self-inflict shocks.

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Technology and innovation are fundamental to unlocking the potential of Canada’s energy resources. For more than a century, Imperial has been investing in research, including at our Sarnia and Calgary research centres, to enhance environmental performance, production efficiency and product quality. Sustainability Topic.

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Our laboratory demonstrated previously that spontaneously hypertensive rats (​SHR) exhibited an elevated basal Fos expression in the nucleus tractus solitarii.

This archive was generated by hypermail 2. Re: FOS Newsletter Excerpts This message : [ Message body ] [ More options top , bottom ] Related messages : [ Next message ] [ Previous message ] [ Maybe in reply to ] [ Next in thread ] Contemporary messages sorted : [ by date ] [ by thread ] [ by subject ] [ by author ] [ by messages with attachments ]. So I apologize that this issue arrives only six days after the last one. The reason is that tomorrow I’ll be busy with other obligations and the day after that Topica will be down for maintenance.

Besides, I already have an issue’s worth ready to go. Unless there’s an unusual surge of FOS news in the coming days, I’ll give us both a break next week. The Public Library of Science deadline September 1 is now behind us. If you’ve seen news stories, send me the URLs. If you’ve seen news firsthand, send me an account.

Festival of Speed

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